Coffee offers many health advantages, but if you suffer from Mast Cell Activation Syndrome (MCAS) or Histamine Intolerance it could trigger symptoms. Coffee contains chemicals including histamine and caffeine which are natural body substances used by your immune system to get rid of allergens, reduce inflammation and promote gut health and digestion – yet too much histamine levels in your system could lead to an intolerance buildup and lead to symptoms such as hives, heart palpitations, itching rashes or anxiety resulting in severe flare ups!

Histamine intolerance may also be caused by foods that block histamine oxidase, an enzyme responsible for breaking down histamine in your body. DAO inhibitors (histamine oxidase inhibitors) can be found in various food items – coffee beans being one such example since their fermentation process generates histamine which remains within them when ground and roasted – eventually making its way into your cup of coffee!

Histamine levels in coffee depend on various processes used during its growth and manufacturing stages, from fermentation to roasting; some coffee may not even contain histamine due to being non-fermented; in others however histamine levels can be reduced through roasting; nevertheless neither type of coffee is free of histamine-causing chemicals such as acrylamides and PAHs that form from burning coffee during roasting; these can trigger inflammation as well as being carcinogenic – thus the amount you drink could vary significantly!

One effective strategy for avoiding histamine in coffee is choosing organic and mold-free varieties that have been third party tested for histamine and mycotoxins, while simultaneously decreasing aflatoxin, ochratoxin A, and other molds which produce histamine. Another way is purchasing cold brew coffee that has not been heated during roasting process as this may reduce PAHs and acrylamides levels; also opting for coffee that contains less histamine while chemical free will aid liver detoxification as well as parasympathetic nervous system signaling and Vagus nerve stimulation needed for healthy histamine response and MCAS relief.